Investing

How to Evaluate an IPO Before Investing

Initial Public Offerings (IPOs) can offer exciting opportunities to invest early in companies transitioning to public markets. However, evaluating an IPO requires a disciplined and strategic approach. With companies often presenting a best-case scenario in their prospectus, investors need to know what to look for — and what to question. This guide explores the key factors to evaluate before investing in any IPO.

Understand the Company’s Business Model

Before investing, ask: What does the company do? How does it make money? Is the business model scalable? A company with a clear, understandable, and proven business model is generally a safer investment than one relying on unproven concepts or future technologies that are still in development.

Top Biotech IPOs to Watch in 2025

The biotechnology sector continues to be a focal point for investors seeking groundbreaking innovations and substantial growth opportunities. As we progress through 2025, several biotech companies are preparing to make their debut on the public markets. This article provides an overview of the top biotech IPOs to watch this year, highlighting their key developments, financial health, and potential market impact.

1. Metsera, Inc.

Metsera, founded in 2022 by ARCH Venture Partners and Population Health Partners, has rapidly positioned itself as a notable player in the weight-loss therapeutics arena. The company’s primary focus is on developing both injectable and oral drugs targeting obesity, utilizing the GLP-1 mechanism among other biological pathways. Their lead product candidate, MET-097i, an injectable formulation, demonstrated promising results in mid-stage trials, showing an average weight loss of 11.3% in patients.